Researchers propose a novel biomarker for early diagnosis of Alzheimer'sdisease
The ongoing search for therapeutic interventions in Alzheimer disease has highlighted the complexity of this condition and the need for additional biomarkers, beyond amyloid-β and tau, to improve clinical assessment. Astrocytes are brain cells that control metabolic and redox homeostasis, among other functions, and are emerging as an important focus of AD research owing to their swift response to brain pathology in the initial stages of the disease.
Experimental work using α7nAChRs agonists suggests that through the modulation of reactive astrogliosis, Aβ spreading might be prevented at an early stage of AD. A multitracer imaging approach with astrocyte and α7nAChR PET radiotracers is essential to further explore the role of α7nAChRs and their interplay with reactive astrogliosis across the AD continuum.
France Dernières Nouvelles, France Actualités
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