Components of cytoskeleton found to strengthen effect of sex hormones nature
Steroid hormone receptors are ligand-binding transcription factors essential for mammalian physiology. The androgen receptor binds androgens mediating gene expression for sexual, somatic, and behavioral functions, and is involved in various conditions including androgen-insensitivity-syndrome or prostate cancer. Here we identified functional AIS-patient mutations in the formin and actin nucleator
. was enriched in the nucleus, where its localization correlated with that of the AR to form actin-dependent transcriptional droplets in response to dihydrotestosterone. -AR-droplets ranged from 0.02 to 0.06 µmin size and associated with active RNA polymerase II. polymerized actin directly at the AR to promote droplet coalescence in a highly dynamic manner and nuclear actin polymerization is required for prostate-specific antigen expression in cancer cells. Our data uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.
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