The absence of a specific serotonin receptor has been linked to a reduction in previously acquired fear responses. Serotonin, a neurotransmitter, plays a crucial role in both the development and the elimination of fear and anxiety. A research team from the Department of General Zoology and Neurobio
The researchers investigated how the absence of a specific receptor affects the ability to unlearn fear.
Serotonin, a neurotransmitter, plays a crucial role in both the development and the elimination of fear and anxiety. A research team from the Department of General Zoology and Neurobiology atin Germany, led by Dr. Katharina Spoida and Dr. Sandra Süß, has been studying the underlying mechanisms of this process.
Knowing that the neurotransmitter serotonin plays an important role in the development of fear, the research team explored its role in extinction learning, i.e. the unlearning of fear, in greater detail. To this end, they examined so-called knock-out mice that lack a certain serotonin receptor – the 5-HT2C receptor – due to genetic modifications. These mice learned in one day to associate a certain sound with a mild but unpleasant electrical stimulus.
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