Study finds higher levels of common diet-associated microbe elevates heartfailure risk CellCellPress
The gut microbiota-dependent metabolite phenylacetylgutamine is both associated with atherothrombotic heart disease in humans, and mechanistically linked to cardiovascular disease pathogenesis in animal models via modulation of adrenergic receptor signaling.Here we examined both clinical and mechanistic relationships between PAGln and heart failure .
Circulating PAGln levels were dose-dependently associated with HF presence and indices of severity independent of traditional risk factors and renal function in both cohorts.
France Dernières Nouvelles, France Actualités
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