A Review article published in Crit_Care discusses dysbiosis in critical illness and outlines potential strategies—such as nutrition, probiotics, fecal microbiota transplantation—to modulate the gut microbiota in ICU patients and restore eubiosis.
FMT has also been studied in TBI, which causes autonomic dysregulation, impaired BBB integrity, intestinal mucosal impairment, and brain immunity dysregulation. A recent study evaluated the effect of FMT following TBI in rats with a controlled cortical impact model, showing that this strategy could effectively restore eubiosis and resolve neurological deficits [The emerging literature represents a great starting point for the exploitation of FMT in different ICU conditions and complications.
The pathobiota composition is one of the leading causes of clinical complications. Metagenomic and meta-metabolomic studies are growing and dissecting mechanisms leading to dysbiosis in different ICU conditions. Harnessing the GM in ICU patients is intriguing, and this review summarizes the currently available results and outlines potential strategies for critically ill patients.
France Dernières Nouvelles, France Actualités
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