Nature research paper: YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
) and secretion of SASP factors after ex vivo genetic ablation of YAP/TAZ in primary mouse adult fibroblasts . Secretion of TNFα, a necrosis marker, was not detected., Heatmaps showing upregulation of SASP in WI-38 human fibroblasts upon siRNA-mediated depletion of YAP/TAZ ., RT–qPCR analysis showing induction of SASP marker genes in adventitia-denuded aortic mediae from SMC-Y/T cKO compared to control mice. Data are presented as mean ± s.d.
MAFs were isolated from young and oldmice, left untreated or treated with doxycycline to sustain YAP activity ex vivo. Related to Fig., SA-β-Gal staining and quantification in primary MAFs isolated from young and old mice, in the presence or absence of constitutively active YAP5SA . Cells transduced with empty vector are indicated as Control. Quantification data are presented as mean ± s.d.
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