Unlocking Alzheimer’s: New Study Reveals Early Stage Mechanisms

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Unlocking Alzheimer’s: New Study Reveals Early Stage Mechanisms
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A new study reveals that in Alzheimer’s disease, a fragment of the amyloid precursor protein disrupts key cellular processes, potentially causing early neuron death. This finding suggests that AD treatments should focus on preventing APP-CTF accumulation.disease continues to be a significant and widespread neurodegenerative condition, impacting millions globally.

APP-C-Terminal Fragments accumulate between the endoplasmic reticulum and the lysosomes. Credit: VIB For a long time, it was thought that blocking gamma-secretase would be the logical step to prevent the production of toxic Aβ fragments. However, this leads to the accumulation of their precursor, the APP-C-Terminal Fragments, or APP-CTFs. Now, the researchers have discovered that these fragments are also toxic to neurons.

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