IF you are looking for beautiful beaches without the crowds, there is a holiday destination just a few hours from the UK. And with cheap flights and hotels, it won’t break the bank this summe…
Lastminute.com has seven-night deals with return flights for as little as £318.
If you fancy all-inclusive, you can stay at the Royal Grand Hotel & Spa hotel for less than £700 each, with flights included.Or you can book your own hotels and apartments which start from £30, with Wizz Air flights from £38 return to Varna.Tourists often praise it as being "clean and not too overcrowded" as well as being good for kids.
There are also beach showers and restaurants and cafes across the pier, along with umbrellas you can rent for around £2. Down the road is also Bendida Beach, which tourists have likened to Greece and said is the most "beautiful beach in the country".The resort became popular in the Noughties due to the annual Kavarna Rockfest, which attracted acts such as Alice Cooper and Motorhead.What else do I need to know about Kavarna?is currently three hours ahead of the UK.
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Researchers identify novel genes that may increase risk for schizophreniaResearchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.
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Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain - BMC Medical GenomicsBackground Our understanding of the molecular underpinnings of chronic traumatic encephalopathy (CTE) and its associated pathology in post-mortem brain is incomplete. Factors including years of play and genetic risk variants influence the extent of tau pathology associated with disease expression, but how these factors affect gene expression, and whether those effects are consistent across the development of disease, is unknown. Methods To address these questions, we conducted an analysis of the largest post-mortem brain CTE mRNASeq whole-transcriptome dataset available to date. We examined the genes and biological processes associated with disease by comparing individuals with CTE with control individuals with a history of repetitive head impacts that lack CTE pathology. We then identified genes and biological processes associated with total years of play as a measure of exposure, amount of tau pathology present at time of death, and the presence of APOE and TMEM106B risk variants. Samples were stratified into low and high pathology groups based on McKee CTE staging criteria to model early versus late changes in response to exposure, and the relative effects associated with these factors were compared between these groups. Results Substantial gene expression changes were associated with severe disease for most of these factors, primarily implicating diverse, strongly involved neuroinflammatory and neuroimmune processes. In contrast, low pathology groups had many fewer genes and processes implicated and show striking differences for some factors when compared with severe disease. Specifically, gene expression associated with amount of tau pathology showed a nearly perfect inverse relationship when compared between these two groups. Conclusions Together, these results suggest the early CTE disease process may be mechanistically different than what occurs in late stages, that total years of play and tau pathology influence disease expression differently, and that rela
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