Ultrapotent IgM antibodies isolated from a pregnant woman with Zika virus show promise as an immunotherapy Antibodies Immunotherapy Virus ZikaVirus IgM CellCellPress DukeMedSchool LifeAtPurdue NIAIDNews IcahnMountSinai
By Dr. Liji Thomas, MDNov 22 2022Reviewed by Danielle Ellis, B.Sc. This shows the importance of such antibodies in protecting the fetus against the Zika virus while presenting a possibly useful antibody for preventing fetal infection.
Earlier studies have primarily reported nAbs of the immunoglobulin G class, even though IgM antibodies play a surprisingly prolonged role in flavivirus infections such as yellow fever virus and West Nile virus infections. This is based on the conventional concept of IgM antibodies being formed transiently during the acute phase of infection, comprising low-affinity antibodies lacking neutralizing capacity. However, this belies the early neutralizing IgM antibodies in such infections.
B cells are first stimulated to release interleukin , then their production is suppressed, allowing mature B cells to survive but reducing naïve B cell numbers during pregnancy. Since the latter produce IgM antibodies, this shift to memory and antibody-secreting cells shapes the profile of IgG and IgM nAbs during pregnancy.
However, four of the seven women with late IgM antibodies showed neutralizing capacity at up to ~210 days from symptom onset, all being secondary cases. Interestingly, the bulk of ZIKV-reactive IgM was not made up of ZIKV-neutralizing IgM.This led to the identification of nine separate B cell lines that produced ZIKV-binding antibodies in the peripheral blood of ZIKV-infected mothers. In addition, these B lymphoblastoid cell lines were found to include one that produced the IgM antibody DH1017.
Here again, “the decavalent DH1017.IgM pentamer protects against ZIKV disease in mice and controls viremia more efficiently than the bivalent DH1017.IgG monomer.” What are the implications? Based on mouse findings, DH1017.IgM looks like a good candidate for immunotherapy against ZIKV. Like other flaviviruses, ZIKV induces persistent IgM antibodies that could help neutralize the virus within the first three months of pregnancy.
France Dernières Nouvelles, France Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Approved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancyApproved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancy PUCRS vaccine vaccination virus virology disease respiratory
Lire la suite »
Warning to parents over ‘highly-contagious’ virus targeting kids this winterPARENTS must be on the look out for a potentially deadly but also common bug increasing among kids this winter, experts have warned. Respiratory syncytial virus (RSV) is a chest infection that…
Lire la suite »
Study shows sylvatic origin of chikungunya virus transmission among nonhuman primates of MyanmarResearchers investigated the potential exposure of peri-urban non-human primates (NHPs) residing near Yangon to arboviruses that have raised health concerns.
Lire la suite »
WHO‒recommended alcohol-based hand rub formulations show efficacy against Monkeypox virusResearchers demonstrated the efficacy of two World Health Organization (WHO)‒recommended alcohol-based hand rub solutions to inactivate the monkeypox virus (MPXV).
Lire la suite »
Kiwira virus: a new bat-borne hantavirus detected in AfricaKiwira virus: a new bat-borne hantavirus detected in Africa Hantavirus Virus Bats Africa VirusesMDPI HumboldtUni rki_de NM_AIST inrb_kinshasa ComeniusUni
Lire la suite »
Epidemiological and clinical characteristics of monkeypox virus infection in cis and trans women and non-binary individualsEpidemiological and clinical characteristics of monkeypox virus infection in cis and trans women and non-binary individuals TheLancet QMUL Sorbonne_Univ_ UofT monkeypox women nonbinary virus infection disease
Lire la suite »