Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients biorxivpreprint unidue ChariteBerlin SARSCoV2 inflammation inflammatory covid coronavirus COVID19
By Bhavana KunkalikarDec 13 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers assessed the association of enhanced migratory or activated CD8+ T cell and reduced avidity reactive cellular response due to post-acute coronavirus disease 2019 syndrome .
About the study The present study investigated the immunological response in 40 COVID-19 patients with non-specific PASC and 15 healthy COVID-19 convalescent donors. Results The study group consisted of individuals who tested SARS-CoV-2 negative via nasal swab testing at the time of enrolment. During the acute period of COVID-19, 96% and 100% of the PASC and control cohorts exhibited moderate COVID-19 severity without needing hospitalization, while 4% were seriously or critically ill and were hospitalized, respectively.
Furthermore, PASC patients had a significantly increased frequency of CD4+ and CD8+ T cells that co-expressed CCR5 and CXCR3, as well as CD4+ T cells that co-expressed EB12 and CCR5 in comparison to the control subjects.
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