What is the incidence of viral rebound after treatment with nirmatrelvir-ritonavir and molnupiravir? JAMANetworkOpen virus COVID19 coronavirus covid antivirals antiviral SARSCoV2
By Pooja Toshniwal PahariaDec 12 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in JAMA Network Open, researchers evaluated the incidence of coronavirus disease 2019 rebound among SARS-CoV-2 -positive patients treated with oral antiviral drugs such as nirmatrelvir-ritonavir combination and molnupiravir. They also described the clinical outcomes among community-dwelling patients hospitalized due to the viral rebound of SARS-CoV-2 infections.
About the study In the present retrospective cohort study, researchers evaluated the incidence of COVID-19 rebound post-treatment with molnupiravir and nirmatrelvir-ritonavir among community-dwelling individuals. They investigated whether the rebound was related to the clinical outcome of COVID-19. Results Related StoriesAmong 12,629 COVID-19 patients, the average age was 65 years, and 53% were men. In total, 93% of the study participants did not use oral antivirals, six percent of the patients used molnupiravir, and two percent of the participants used nirmatrelvir-ritonavir.
COVID-19 rebound was observed among six patients treated with molnupiravir , two patients treated with nirmatrelvir-ritonavir , and 68 individuals who were treated with none of the antiviral medications . Most of the COVID-19 rebounds were observed 2.0 days to 5.0 days post-completion of the antiviral treatment course.
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