Researchers have zeroed in on C. auris' uncanny ability to stick to everything from skin to catheters and made a startling discovery: it uses a protein similar to that used by barnacles and mollusks.
In 2009, a mysterious fungus emerged seemingly from out of thin air, targeting the most vulnerable among us. It sounds like Hollywood, but the fungus in question poses a very real threat. Scientists are scrambling to figure out what makes the life-threatening fungustick -- and why even the best infection control protocols in hospitals and other care settings often fail to get rid of it.The investigative team, led by Teresa O'Meara, Ph.D.
Furthermore, the team discovered that SCF1 was associated with increased colonization and an enhanced ability to cause disease. Using mouse models, they demonstrated that a loss of both SCF1 and IFF4109 diminished the ability of a strain of C. auris to colonize skin and an in-dwelling catheter. What's more, strains designed to over express SCF1 saw enhanced virulence and more fungal lesions."We don't know why this adhesin is required to cause disease," said O'Meara.
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