Recent research conducted by the Universities of Bonn and Heidelberg sheds light on a carefully choreographed dance. Nerve cells require vast amounts of energy and oxygen which they receive through the bloodstream. This results in nerve tissue being densely intertwined with numerous blood vessels.
, in collaboration with international partners, have uncovered a mechanism that ensures this coordination. The findings have recently been published in the journalNerve cells are highly energy-intensive, requiring a large amount of fuel. Approximately 20% of the calories we consume through food are dedicated to our brain, as the generation of voltage pulses and transmission between neurons is incredibly energy-demanding.
The working group with Prof. Dr. Carmen Ruiz de Almodovar – and José Ricardo da Cruz Vieira . Credit: AG Ruiz de Almodovar/University of Bonn The blood vessels in the spinal cord – receive a “do not disturb” signal from the neurons at certain times during embryonic development. That way they avoid getting in each other’s way. Credit: José Ricardo da Cruz Vieira/University of Bonn
But how is this dance coordinated? Apparently, by the motor neurons shouting a “stop, now it’s my turn” message to the vascular cells. To do this, they use a protein that they release into their environment – semaphorin 3C . It diffuses to the vascular cells and docks there at a receptor called PlexinD1 – in a sense, this is the ear for which the molecular message is intended.
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