Recent therapeutic strategies for renal cell carcinoma and the effects of the tumor microenvironment on systemic therapy Cancers_MDPI cancer carcinoma renalcellcarcinoma therapy tumor tumormicroenvironment
By Bhavana KunkalikarFeb 6 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Cancers, researchers explored the association between the human microbiome and improved renal cell carcinoma outcomes.
The standard treatment for patients having localized RCC is complete surgical tumor resection. Previously, patients diagnosed with metastatic disease were treated with cytokines like interleukin-2 and interferon-ɑ to stimulate the antitumor immune response. Tyrosine kinase inhibitors , which include the mechanistic target of rapamycin inhibitors along with vascular endothelial growth factor antibodies, are commonly utilized as targeted medications and are regarded as anti-angiogenic treatments.
In RCC treatment, it is crucial to assess the TME since it influences the therapeutic response. Current mRCC treatments aim to obstruct the growth of new blood vessels, or "angiogenesis," and to target the tumor cells. A study also revealed that Streptococcus, Blautia, Romboutsia, [Ruminococcus] torques group, and [Eubacterium] hallii group were prevalent and positively related with ccRCC. Streptococcus lutetiensis specifically enhanced ccRCC proliferation, invasion, and migration in-vitro through the TGF-signaling pathway, which may be a therapeutic target for RCC. On the other hand, another study observed that the species diversity in RCC tissues was notably diminished.
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