New immunotherapy holds promise for ovariancancer
," says the study's joint last author Isabelle Magalhaes, docent at the Department of Oncology-Pathology at Karolinska Institutet."Despite many improvements to the available therapy, the prognosis for women with ovarian cancer is still poor.""Tumors often arise in an environment that's unfavorable for T cells, in part due to a low oxygen level," says Jonas Mattsson, visiting professor at Karolinska Institutet, and the second join last author.
Many ovarian tumors contain mesothelin, and the researchers wanted to test three types of CAR molecule programmed to attack this particular protein. They therefore repeatedly exposed ovarianAll three CAR T-cells significantly prolonged the lives of the mice with cancer compared to those in the, with the type called M1xx CAR T cells proving the most efficacious.
"Hopefully, this discovery will pave the way for a clinical study," he says."Our goal is to predict the optimal conditions for producing CAR T cells able to infiltrate and attack the tumor and survive in the bodies of women with ovarian cancer."Tuned activation of MSLN-CAR T cells induces superior anti-tumor responses in ovarian cancer models,
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