Hormonal treatment in pregnancy won't lower odds for pretermbirth jamanetworkopen
Third, we sought to ascertain whether PTB was associated with progesterone levels among patients treated with VP. Plasma progesterone levels were measured at 24 and 32 weeks, coinciding with routine blood samples obtained for prenatal care. Progesterone was measured based on methods described by Honda et al.The association of progesterone blood levels with PTB was also compared with the rate of adherence.
Fourth, we compared pregnancy outcomes for patients who declined any use of progestogens during the study with those treated with VP to address selection bias of the study cohort. Pregnancy outcomes for patients who declined progestogen use during the study period were analyzed for both PTB history and gestational age at delivery. This analysis included comparison of specific PTB profiles according to patient history.
The overall rate of recurrent PTB was 24.0% for the VP cohort compared with the 16.8% expected rate in the matched historical Parkland obstetric population (
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