China and India have recently approved nasal vaccines, but the U.S. won’t be following any time soon, experts say. Here's why
summarizing later stage trials said these levels of antibodies were higher among the people receiving the inhaled dose compared to the injected one.
That’s because there are no widely accepted ways to document the effects that a mucosal vaccine is having on the immune system. Scientists have much less experience with mucosal vaccines, and only a handful are approved, including one for influenza and the oral polio vaccine. That makes it difficult for health authorities to measure what the vaccines are doing and to know whether they’re providing protection above and beyond existing vaccines.
Philanthropic organizations including CEPI, the Wellcome Trust, and the Bill and Melinda Gates Foundation are convening a workshop in early November to formulate ways to bridge the gap between animal and human studies of nasal vaccines. The groups are focused on finding sustainable and broadly applicable vaccine strategies for fighting infectious diseases—including a pan-coronavirus vaccine that targets multiple and potentially future strains—and a nasal-based approach is one of them.
Dozens of other nasal vaccines in development are showing promise in animal studies. To avoid the potential challenges of vaccines such as AstraZeneca’s, which used another virus to deliver the SARS-CoV-2 genes, Iwasaki is exploring two other strategies for a nasal vaccine.
France Dernières Nouvelles, France Actualités
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