TTP is a blood disorder caused by a faulty enzyme called ADAMTS13. The result is blood clotting in the body, which can lead to blocked blood flow to critical areas - via healthing_ca .RareDiseases raredisorders rarediseaseday MD_Canada ...
TTP is a blood disorder caused by a faulty enzyme called ADAMTS13,the National Heart, Lung and Blood Institute. The result is blood clotting in the body, which can lead to blocked blood flow to critical areas, like the brain or lungs. Excessive clotting also means that there aren’t enough platelets in the body to stop other sources of bleeding, which can cause easy bruising, difficulty dressing wounds and internal bleeding.
[The jugular] is probably the more comfortable way. I mean, they have to stick a lot of holes in your arm. If you think of the size of a person [and] how much blood you have — half that blood is plasma. It’s litres of plasma that you need to replace, so there’s a lot of flow needed in order to do that. If you’re using the arms, the holes are small, and it takes a long time. But when you have the line in your neck, it’s much more efficient.
It can be risky though — the thing about not having platelets is that you bleed, so putting a line in someone’s neck when their platelets are low is something to think about. TTP is treated by exchanging plasma to remove the antibodies that inhibit the ADAMTS13 enzyme and causes clotting of the platelets and replaces it with normal ADAMTS13. SUPPLIEDI’ve had occurrences of TTP five times. There’s this flurry of having your plasma exchanged, and then when everything gets back to normal you go back to your normal life. You really don’t do anything to prevent it after that. The only thing I do is get my blood tested once every month.
Another drug which is very new — it’s been approved by Health Canada but it hasn’t been approved to be paid for — is called
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