Weekly weight loss drug reduces BMI in teens ChildHealth Obesity WeightLoss NEJM
By Benedette Cuffari, M.Sc.Nov 3 2022Reviewed by Aimee Molineux Semaglutide is a glucagon-like peptide-1 analog that can reduce hunger, thus supporting weight loss. In a recent New England Journal of Medicine study, researchers report that a weekly dose of semaglutide led to a significant body mass index reduction in adolescents.
Although certain lifestyle changes can improve the quality of life in young obese individuals, their effects are often limited in their ability to significantly reduce BMI values. As a result, several pharmacological agents have been approved to support long-term weight maintenance, some of which include liraglutide, orlistat, and phentermine-topiramate.
Each study participant was randomly assigned to receive either a once-weekly 2.4 milligram dose of semaglutide or placebo that was administered subcutaneously for a total of 68 weeks. In addition to the placebo or drug, all study participants also entered a 12-week lifestyle intervention that involved counseling about healthy diet options and physical activities that could support weight loss.
The mean age of the study participants was 15.4 years, 62% of whom were female and 79% were White. The mean body weight was 107.5 kg and a mean BMI was 37.0. After the medication was discontinued, the study participants in both groups continued to receive lifestyle interventions for an additional seven weeks. By the end of this period, or week 75, the BMI of semaglutide recipients remained below their baseline value, whereas those who received the placebo had a BMI that exceeded their baseline value.
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Once-Weekly Semaglutide in Adolescents with Obesity | NEJMOriginal Article from The New England Journal of Medicine — Once-Weekly Semaglutide in Adolescents with Obesity
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