The world's first medical trial authorised to deliberately expose participants to the coronavirus is seeking more volunteers as it steps up efforts to help develop better vaccines.
Researchers are close to establishing the weakest possible virus infection that assures about half of people exposed to it get asymptomatic or mild COVID-19.
"This is the immune response we then need to induce with a new vaccine," said Helen McShane, Oxford University Professor of Vaccinology and the study's chief investigator. Global immunologists have been seeking to pinpoint the immune reaction that a vaccine must produce to shield against the illness, known as a correlate of protection. Once discovered, the need for mass vaccine trials is greatly reduced.Scientists have used human challenge trials for decades to develop treatments against many infectious diseases, but this is the first known such research into COVID-19.
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