Omicron infection “enhances preexisting immunity elicited by vaccines but, on its own, may not confer broad protection against non-Omicron variants in unvaccinated individuals”: study
The researchers used mice and blood samples from donors infected with the Omicron variant, and realised that this variant creates only a weak immune response. So how do humans react?
“This research underscores the importance of staying current with your vaccinations, even if you have previously been infected with the Omicron variant, as you are still likely vulnerable to re-infection,” says co-senior author Jennifer Doudna, PhD, who is a senior investigator at Gladstone, a professor at UC Berkeley, founder of the Innovative Genomics Institute, and an investigator of the Howard Hughes Medical Institute.
The researchers summed up their findings about the immune response generated by Omicron infections. They found that in mice infected with the Omicron variant, even though they displayed milder symptoms, their immune systems came up with the T cells and antibodies typically seen in response to other viruses.
If the animals had been uninfected by the coronavirus, their blood could not neutralise any of the five virus variants – that is, block the ability for them to replicate. “Samples from WA1-infected animals could neutralise Alpha, and, to a lesser degree, the Beta and Delta virus –– but not Omicron,” the news release notes. “Samples from Delta-infected mice could neutralise Delta, Alpha and, to a lesser degree, the Omicron and Beta virus.
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