Science, Space and Technology News 2023
Genetically testing around a thousand embryos, scientists found that nearly half underwent developmental arrest due to genetic errors occurring after fertilization, shedding light on challenges faced in IVF and natural conception. The research suggests that IVF treatments could be improved by understanding these genetic mishaps and potentially altering the IVF process.
A time-lapse clip of a common type of abnormal cell division where an embryo cleaves directly from a single-celled zygote into three cells. The new research shows such abnormal division is strongly associated with chromosome abnormalities and embryo arrest. Credit: Christian OttoliniHuman cells typically receive 46 chromosomes, 23 from each parent. The team discovered nonviable embryos started with the 46-chromosome set, but then passed down incorrect numbers of chromosomes as cells divided.
, McCoy said, the findings could help explain why pregnancy loss and miscarriage are so common in humans.“Aneuploidy is an example of an extremely strong type of natural selection that’s going on every generation in humans,” McCoy said. “It might just be a feature of human reproduction and development, but it has implications for IVF. So in the long term, we hope that we can improve genetic testing and improve IVF outcomes.
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