U.S. warns monkeypox could mutate to resist antiviral drug

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U.S. warns monkeypox could mutate to resist antiviral drug
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U.S. health officials are warning against overuse of the lone drug available to treat monkeypox, saying that even a small mutation in the virus could render the pills ineffective.

WASHINGTON —

The call to scale back Tpoxx’s use follows weeks of criticism from HIV advocates and other patient groups who have urged the Biden administration to make the antiviral drug more widely available. Tpoxx is approved for the related smallpox virus, and its use against monkeypox is considered experimental and tightly controlled by federal officials.

During a White House briefing, CDC Director Dr. Rochelle Walensky attributed the decline to vaccinations, educational outreach and individuals reducing behaviors linked to spread. The vast majority of U.S. cases have been in men who have sex with men, though officials emphasize that the virus can infect anyone.Dr. Anthony Fauci, the nation's top infectious disease official, noted that resistance is always a risk when using antiviral drugs.

But no changes were made to allow emergency use of Tpoxx, stoking complaints from groups representing gay and bisexual men.

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