The number and volume of emergent ischemic lesions following carotid artery stenting may be reduced with use of ticagrelor vs clopidogrel, secondary findings of the PRECISE-MRI trial suggest.
Adding the drug to aspirin is also superior to aspirin alone in preventing recurrent stroke in patients with minor stroke orTo examine whether ticagrelor is superior to clopidogrel as an add-on to aspirin in preventing ischemic brain lesions during CAS, the team conducted a randomized, open, active-controlled trial.
The study included 14 sites in Belgium, Germany, Italy, the Netherlands, Switzerland, and the United Kingdom. Enrollment was stopped after 209 of the originally planned 370 patients,"due to slow recruitment and a lack of further funding," Bonati said. Bonati showed that there was no significant difference in the primary efficacy outcome of the presence of ≥ 1 new ischemic brain lesion on the second or third MRI, at 74.7% for patients given ticagrelor versus 79.8% with clopidogrel, or a relative risk of 0.94 .