A woman has been in remission from HIV for 14 months after being treated for leukemia with transplants of adult stem cells and umbilical cord blood.
Feb. 15, 2022 -- If she remains off treatment without any hint of HIV, she would be only the third person in the world – and the first woman -- to be cured through a transplant.
But in 2017, she was diagnosed with leukemia. As a last resort to cure her of the cancer, she received a combination of adult stem cells from a relative’s blood and umbilical cord blood obtained from a cord-blood bank. That sample of cord blood was selected because it contained a genetic mutation that makes the immune system resistant to HIV.
One hundred days after the transplant, the immune system contained within the cord blood had taken over. After 27 months, she decided to stop all HIV treatment to see if the transplant had worked. Most donors with the gene mutation this patient received are white, Bryson said, suggesting that this approach, in a woman of multiple races, could expand the pool of people living with HIV and cancer who are good candidates for it.
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