Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.
ArticleBody:This article was originally featured on Knowable Magazine. Every second, as we breathe, sleep, eat and go about our lives, millions of biochemical reactions are happening in our cells. Among the hurly burly of chemical exchanges are ones that attach small carbon molecules onto proteins, fats, DNA and more. Adding or taking away these small molecules is essential for many reactions that enable cells to survive, grow and divide.
Credit: Knowable Magazine Other work by Tu’s group suggests that histones may play an even more central role in metabolic pathways, this time involving methyl groups. Again in yeast, the scientists studied a chemical that carries methyl groups around — its name is SAM for short. When SAM gives up a methyl group, it turns into a chemical that is needed to make the amino acid cysteine.
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