The COVID-19 pandemic and advances in data science, AI & technology all exposed limitations and spurred changes in the clinicaltrials landscape. In his Perspective, VivekSubbiah discusses these issues and shares his vision for the future MDAndersonNews
. Many academic institutions are entering into risk-sharing strategic alliances with the pharma industry to collaborate across preclinical and clinical development phases. Such successful innovative partnership models have set a precedent in diseases such as cystic fibrosis, multiple myeloma, type 1 diabetes mellitus and other rare diseases
. These collaborations have effectively catalyzed innovation through all phases of drug development and provided a compelling reason to sustain and foster more of these sorts of programs.Social media outlets can influence patient accrual in clinical trials. They can strongly influence and address historical clinical trial challenges, including the lack of awareness among patients and physicians about available trials and the lack of community engagement. More than 4.
People with terminal diseases often self-experiment with drugs, and online patient communities can provide environments for sharing and monitoring such drug usage. This can allow for observational studies to be planned around quantitative, internet-based outcome data. For example, researchers developed an algorithm to dissect the data reported on the PatientsLikeMe website by people with amyotrophic lateral sclerosis who experimented with lithium carbonate treatment.
An increase in engagement from patients and patient advocacy groups can aid patient education and outreach and can facilitate patient-partnered research, as well as allowing for incorporation of patients’ perspectives in the design of clinical research—ultimately generating research that is driven by the needs of real people with the disease under investigation.
Current paradigms must be continuously challenged by emerging technology and by all stakeholders . Disruptive innovation should lead to every clinical site being a research site, with all necessary quality checks and research as part of the standard of care. The healthcare system should be integrated into an intuitive RWE-generation system, with clinical research and clinical care going hand in hand.
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