The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines GWtweets JohnsHopkins Penn vaccine vaccination malaria mRNA lipidnanoparticle
By Neha MathurFeb 13 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in NPJ vaccines, researchers evaluated the immunogenicity of two vaccine candidates, Pfs25 and PfCSP, based on the messenger ribonucleic acid -lipid nanoparticle platform.
Thus, malaria vaccine development has focused on antigens expressed during various stages of its life cycle. Any transmission-blocking response by a vaccine intervenes with both sexual- and mosquito stages is crucial in malaria eradication efforts. Further, the team performed mosquito standard membrane feeding assays to evaluate immunoglobulin G in serum from final bleeds from each mouse. To this end, they evaluated mice vaccinated with 3 μg and 10 μg Pfs25 mRNA-LNP thrice and also compared mice that received 30 μg Pfs25 only with recipients of mRNA-LNP combination post-four vaccinations.
Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Finally, the researchers evaluated the protection conferred by PfCSP in an in vivo model using sporozoites of P. berghei, a transgenic organism expressing PfCSP and PbPfCSP-green fluorescent protein-luciferase .
SMFAs revealed strong transmission reversing and blocking activities amid low IgG concentrations by all three doses of Pfs25 mRNA-LNP. Pfs25 doses as low as 0.1 μg elicited substantial TRA, which enhanced the effect of higher vaccine doses. On the contrary, PfCSP mRNA-LNP elicited modest antibody responses following one vaccination only and increasingly strong responses after each following dose or boosting. Four doses made immunized mice completely protected against parasite challenges. The co-immunization of Pfs25 and PfCSP induced similar antibody responses and functional activity as a single antigen mRNA-LNP.
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