The convergence of epigenetics and math to predict and intercept cancer cell behavior sciencemagazine
that drive it. In particular, the measurement of entropy can now be applied to epigenetics. As cancers develop, the epigenetic information controlling cell behavior is eroded, and we can identify the locations in the epigenome where this occurs and the genes that drive this increased entropy, says Feinberg.
"New methods in quantitative analyses of the cancer epigenetic landscape now provide the tools to understand the connections between genetics and other drivers ofand growth and the relationship to epigenetic regulatory networks that mediate the landscape," adds Feinberg, Bloomberg Distinguished Professor of Medicine at the Johns Hopkins University School of Medicine, Whiting School of Engineering and Bloomberg School of Public Health.
New technologies that integrate cancer biology and mathematics may make it possible to distinguish cancer cells from normal cells, and to quantify and measure the epigenetic modulation of cells states and how it influences the behavior of cells, the article reports.that occur only in cancer cells to diagnose cancer better and earlier and predict its behavior, so we can intervene with more targeted therapies," says Feinberg, director of the IBBS epigenetics center.
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