Targeting obesity: findings reveal a new molecular pathway involved in energy homeostasis regulation universitelaval UstaUnisannio obesity homeostasis molecularpathway medicine health wellbeing weight energy
By Pooja Toshniwal PahariaMar 29 2023Reviewed by Lily Ramsey, LLM In a recent study published in Molecular Metabolism, researchers investigated whether under chronic [in obese mice with leptin-associated ob gene mutation ] or acute [six hours of fasting in wild-type mice] reductions in hypothalamic leptin signaling, orexin-A -elicited enhancement in 2-arachidonoyl-glycerol expression led to 2-AG-derived 2-arachidonoyl-sn-glycerol-3-phosphate production, disassembling...
Elucidating the adaptive and maladaptive mechanisms that dysregulate the synaptic refinement of orexin-A OX neurons as a response to the balanced or unbalanced energy intake could improve the understanding of behavioral derangements that affect metabolic health during adiposity. The team recruited 60 males from Molise University's center for research and training in medicine for aging in Italy. Individuals with body mass index above 30 were considered obese according to the World Health Organization criteria. Blood samples were obtained from the participants after overnight fasting to assess serological 2-AGP and OX-A levels.
2-AG and 2-AGP levels were determined using liquid chromatography-mass spectrometry , and OX-A levels were determined using enzyme-linked immunosorbent assays . In addition, 2-AGP upregulation increased pT231-Tau levels in alpha-melanocyte-stimulating hormone projections, regulated by pTyr216-GSK3β signaling pathway activity. 2-AGP and orexin-A expression in obese murine animals and humans strongly correlated.
France Dernières Nouvelles, France Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Amsterdam launches stay away ad campaign targeting young British menThe Dutch city targets UK men aged 18-35 in an ad campaign aimed at changing its reputation.
Lire la suite »
Getting COVID-19 Could Weaken Your Immune SystemA study illustrates how SARS-CoV-2 can damage your immune response
Lire la suite »
Climate change: trees grow for extra month as planet warms - studyScientists compared recent tree growth with detailed notes from a 19th Century Ohio farmer
Lire la suite »
Demographic, geographic, and temporal variables associated with C. auris cases in ItalyDemographic, geographic, and temporal variables associated with C. auris cases in Italy JCM_MDPI AlleConCancro Unibo fungus infection disease infection fungi fungal
Lire la suite »
Smelling other people's sweat could reduce social anxiety, suggests studyApparently, smelling other people’s body odour could provide a calming effect that helps with social anxiety.
Lire la suite »
New study suggests broad neutralizing antibody could provide three years of COVID protectionIn a recent article published in the journal Science Translational Medicine, researchers showed that a novel, lab-engineered monoclonal antibody (mAb), adintrevimab conferred up to 50% protection against symptomatic coronavirus disease 2019 (COVID-19). Furthermore, it demonstrated this exceptional efficacy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–naïve individuals even at titers as low as 1:30.
Lire la suite »