T-cells generated as part of the body's natural immune response to the common cold may help protect against serious illness from COVID-19.
Lalvani says the research at Imperial College found that T-cells generated after a common cold caused by other coronaviruses attack a type of proteins that remain similar across the known COVID-19 variants. These internal proteins are responsible for virus replication, rather than attaching to external cells. That vital role in the virus' evolution gives it far less potential to mutate, he explained.
"The fact that can attack the internal proteins of each of these related viruses [COVID-19 variants] means that they give what's called a broad cross-protection," Lalvani told CBS News."That's in sharp contrast to the surface spike protein, which is the target of antibodies induced by vaccines.
Lalvani said the study should affect how scientists approach the development of future COVID vaccines. "This is now a definitive green light to move forward and develop a T-cell inducing vaccine to internal core proteins, which should protect against current and future variants," he said."We're very fortunate to have found what immunologists refer to as the 'Holy Grail,' so we're keen for people to understand this and to see that, at last, there is a path towards dealing with future variants.
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