Study unlocks clues in mystery of nakedmole-rats' exceptional fertility NatureComms
Unlike humans and other mammals, which become less fertile with age, naked mole-rats can reproduce throughout their remarkably long lifespans. A new study, published today in, sheds light on unique processes that bestow the rodents with what seems like eternal fertility, findings that could eventually point to new therapies for people.
For most mammals, including humans and mice, females are born with a finite number of egg cells, which are produced in utero via a process called oogenesis. Because this limited supply of egg cells depletes over time—some are released during ovulation, but most simply die—fertility declines with age.queens can breed right through old age, suggesting the rodents have special processes to preserve their ovarian reserve and avoid waning fertility.
"This finding is extraordinary," said senior author Ned Place, Ph.D., M.D., professor at the Cornell University College of Veterinary Medicine."It challenges the dogma that was established nearly 70 years ago, which stated female mammals are endowed with a finite number of eggs before or shortly after birth, without any additions being made to the ovarian reserve thereafter."
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