A structural analysis has revealed how the Omicron spike protein maintains binding to the ACE2 receptor. It also illuminated why an antibody that recently completed a phase 1 trial could effectively neutralize the variant, informing antibody drug discovery
In this paper, we report biochemical characterization of the Omicron spike trimer and its binding to ACE2. Our data reveal that the Omicron RBD is less stable and more dynamic than the WT RBD, and the Omicron spike trimer has 6-9 fold increased affinity for binding to ACE2. We further solved the structures of the Omicron spike trimer in the apo state, or bound to ACE2 or an anti-Omicron antibody.
In addition, our structures of antibody-bound Omicron spiker trimer uncover a distinct mode of antibody binding to the spike trimer, in which the unusual RBD-RBD configuration is preserved. The binding epitope of this broad-spectrum antibody is different from previous anti-SARS-CoV-2 antibodies, therefore opening a new venue for antibody drug discovery targeting various strains of SARS-CoV-2, including Omicron.The cryo-EM data were collected at the Shanghai Advanced Electron Microscope Center.
. This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material.
France Dernières Nouvelles, France Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Omicron’s molecular structure could help explain its global takeoverMultiple studies are revealing why the SARS-CoV-2 variant is so transmissible, but also seems to cause milder disease.
Lire la suite »
Russia hits new COVID-19 record; 10x more than a month agoRussia is reporting a record daily count of new coronavirus infections, a tenfold spike from a month ago as the highly contagious omicron variant spreads through the country.
Lire la suite »
Omicron’s molecular structure could help explain its global takeoverMultiple studies are revealing why the SARS-CoV-2 variant is so transmissible, but also seems to cause milder disease.
Lire la suite »
Breakthrough COVID powers up immune response to variants — including OmicronExperiments suggest that SARS-CoV-2 infections after vaccination trigger antibody levels similar to those in people whose infections preceded their vaccination.
Lire la suite »
The Stealth Omicron Variant Is Here: What You Need to KnowWhat you need to know about symptoms and transmissibility.
Lire la suite »