Nature research paper: Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex
. These observations suggest that Ago2 adopts an open conformation by the action of the Hsc70–Hsp90 chaperone machinery, and captures the 5′-phosphate of the guide strand in the siRNA duplex bound to Dicer-2–R2D2. In this way, the Dicer-2–R2D2 heterodimer senses the siRNA thermodynamic asymmetry and facilitates siRNA loading into Ago2 in a fixed orientation, thereby determining which strand of the siRNA duplex is used by Ago2 as the guide strand for target silencing.
Micrographs for Dicer-2–R2D2 were recorded at a nominal magnification of ×105,000, corresponding to a calibrated pixel size of 0.83 Å at the electron exposure of 15.8 e
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