Science, Space and Technology News 2023
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Our genome is essentially stable. Our proteome, though influenced by our health and environment, is largely dependent on what’s encoded by our genes. In contrast, our lipidome can be directly altered, in part, by what we eat and which microbes live inside our gut, making it more malleable and perhaps more responsive to interventions. But the number and variety of lipid molecules – there are at least thousands – has made them hard to study.
For example, more than half of the cataloged lipids were associated with insulin resistance – when the body’s cells cannot use insulin to take up glucose from the blood — which can lead to Type 2 diabetes. Though insulin resistance can be diagnosed by measuring blood glucose, understanding changes to the lipidome helps uncover the biological processes at work.
“It raises the interesting question of whether lipid profiles could predict whether an individual is biologically aging more quickly or more slowly,” said Si Wu, PhD, co-lead author of the study and another former postdoc in Snyder’s lab.
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