Spotting the Seeds of Neurodegeneration – Scientists Develop a Groundbreaking Blood Test for Synucleinopathies — Researchers have engineere |
Scientists have developed a novel assay, IP/RT-QuIC, that detects α-synuclein seeds in synucleinopathy patients’ serum. This assay can differentiate synucleinopathies like Parkinson’s disease, allowing for earlier, precise diagnoses and personalized treatments.
The newly developed assay boasts a range of advantageous features. It is highly sensitive, simple to administer, and yields rapid results. Furthermore, it can discern between different synucleinopathies by detecting structural differences in the amplified seeds. The research was funded by the Japan Agency for Medical Research and Development’s National Research Program for Neurological Disorders and Mental Health.
In this assay, named immunoprecipitation-based real-time quaking-induced conversion , the α-synuclein seeds are isolated from the patient’s serum through immunoprecipitation followed by rapid amplification by real-time quaking-induced conversion . The research team demonstrated that IP/RT-QuIC detected α-synuclein seeds efficiently in patients with neurodegenerative diseases and could distinguish them from people without degenerative diseases . Next, they studied the structural properties of the amplified seeds using transmission electron microscopy . They observed that the synuclein seed structure varied with the type of synucleinopathy.
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