The three-year-old Oakland company is working on two clinical trials for its drug-device combo aimed at setting off a chain of events to destroy brain cancer.
It sounds straight out of"Star Trek," but a serial biopharma entrepreneur and longtime scientist believe their company can selectively, effectively and noninvasively zap the most common form of brain cancer with little more than a drug that sets off tiny particles of light.
SonALAsense's first-in-the-clinic sonodynamic therapy, or SDT, represents an evolution in brain cancer treatments as well as a revolution, its leaders say. Using ultrasound as a way to highlight cancer cells in the brain has been around for years, but that has required opening the skull, and now SonALAsense believes it can turn the process into the cure without surgery., SonALAsense's founder, chief medical officer and chief scientific officer.
Magnetic resonance-focused ultrasound then activates the light through a process known as sonoluminescence, where small, vapor-filled micro-bubbles release their energy as photons, or tiny particles of light. That boosts the amount of"reactive oxygen species," or ROS, which at high levels are thought to wipe out cancer cells.
"I told my wife, 'If I could just get this into humans, I'm sure it could work,'" recalled Marcus, who lives in the New York village of Mount Kisco.
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