Small UK study investigates the effectiveness of a single MVA-BN dose against mpox disease KnowledgeHub ucl mpox disease vaccine vaccination
By Pooja Toshniwal PahariaNov 29 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the Knowledge Hub* preprint server, researchers estimated the single-dose MVA-BN vaccine effectiveness against symptomatic mpox among high-risk gay, bisexual and other men who have sex with men in England.
VE estimates were obtained by adopting the case-coverage or screening approach, in which the vaccination rates among mpox cases were compared to the population coverage. The team used a previously reported calculation to estimate the total number of high-risk GBMSM individuals in England to be 89,240.
The team searched the PubMed database for relevant literature using keywords such as ‘MVA,’ ‘vaccine,’ and ‘monkeypox’ without any time limit using snowball sampling. In addition, the websites of regulatory authorities such as EMA and FDA and preprints pertaining to MVA-BN VE studies during the ongoing 2022 outbreak were searched.
Further, only 460 reported cases had index dates beginning July 4, 2022, onward. As a result, 363 cases were considered for the final analysis. Between week 28 and week 38, 2,018 mpox cases were documented, of which 77% of case individuals had texted their questionnaires. In total, 508 study questionnaires were filled out between 11 July and 25 September . Among 363 confirmed mpox cases, eight occurred ≥2.
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