Slowing progression of, rather than stopping, Alzheimersdisease has measurable benefits for patients and families and may be a more realistic goal for clinical AD drug trials, a new report suggests.
"At the time we started this group, we had one approved treatment and we just knew that there were others on the way and we needed to be prepared to have this conversation and be more proactive than reactive," Christopher Weber, PhD, director of global science initiatives for the Alzheimer's Association and co-author of the report, toldThe work group suggests that simply slowing disease progression might be a desired goal for drug trials, especially early on, before cognition and...
In addition, the report authors call for the development of better research tools to more accurately assess meaningful change. The Clinical Dementia Rating scale is currently the key instrument used as a primary outcome measure in RCTs. However, the report's authors note that it may not be adequate to measure meaningful change in early-stage disease.
"I think the idea of 'clinically meaningful' is truly a socially constructed idea," said Karlawish, co-director of Penn's Memory Center, who did not work on the report. Karlawish added that he's interested in the conversations the report might prompt and the challenges it could highlight, especially when it comes to how meaningful clinical benefit can be measured, regardless of how it's defined.
France Dernières Nouvelles, France Actualités
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