Similar survival observed after transplantation vs chemo in AML OncTwitter
Approximately 50%-70% of patients with AML who receive intensive induction chemotherapy for AML and achieve a first complete remission are referred for post-remission therapy.has shown a benefit for those with a favorable risk profile, patients considered high-risk with adequate performance status may be candidates for allogeneic HCT.
The patients, who had a mean age of 48.2 years, were randomly assigned to consolidation treatment with allogeneic HCT or chemotherapy with high-dose cytarabine , with the option for salvage HCT in the case of relapse. Overall, 12 patients in the HCT group received one consolidation course of high-dose cytarabine after achieving complete remission to bridge until allogeneic HCT, while all other patients in this group received allogeneic HCT directly after induction therapy.
In addition, the rates of nonrelapse mortality at 2 years were higher in the allogeneic HCT group vs chemotherapy . "A charitable interpretation of the results is that a clear, large survival benefit of transplant in first complete remission is not apparent, which in turn can inform decision-making in certain circumstances for patients meeting the trial criteria, [including] younger patients with a readily available donor," he told"However, risk stratification strategies currently used were not followed," he said.
"Although the [study] showed no difference in quality of life in the patient groups, this is likely due to the patient selection," Kasner, of the Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, told."Most patients do not allow themselves to be randomized between these two very different strategies, so those who are willing to be randomized may be a different population in terms how their quality of life is affected by relapse.
France Dernières Nouvelles, France Actualités
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