A study published in Biology of Sex Differences finds that there are sex differences associated with innate immune response in late first trimester placentas but there is no significant difference in healthy full-term placentas.
]. However, sex differences in early formed placental tissues have not been compared with sex differences in adult tissues.
Therefore, we studied sex differences in the placental gene expression in early and late stage pregnancy and compared with adult tissues. We generated RNA and DNA from 30 male and 30 female term placentas from uncomplicated births. We compared sex differences in term uncomplicated placentas to late first trimester placenta samples [] and to 42 non-reproductive adult tissues to better understand the consistency of sex-differential expression across the life span.
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