A single dose of a synthetic version of the mind-altering component of magic mushrooms, psilocybin, improved depression in some people, a new study found.
By Sandee LaMotte, CNN A single dose of a synthetic version of the mind-altering component of magic mushrooms, psilocybin, improved depression in people with a treatment-resistant form of the disease, a new study found.
"If you were in the 25-milligram group, you were nearly three times as likely to respond than if you were in the 1-milligram group," said Johnson, who coauthored safety guidelines for psychedelic research in 2008."The maximum effect seen the day after receiving the treatment. This contrasts with standard antidepressants, which take several weeks to reach maximum effect," said Dr.
Benefits fadedThe clinical trial occurred at 22 sites in the United States, Canada, the UK and seven countries in Europe. The study was designed to test the safety of different dosages of the proprietary version of psilocybin. "Participants were requested to remain off antidepressant treatment during the first 3 weeks after the trial-drug administration; however, these medications could be started at any time during the trial if deemed clinically necessary by a physician investigator," the study said.
"The incidence of sustained response at week 12 was 20% in the 25-mg group, 5% in the 10-mg group, and 10% in the 1-mg group," wrote psychobiologist Dr. Bertha Madras, director of the laboratory of addiction neurobiology at Harvard Medical School's McLean Hospital in Belmont, Massachusetts, in an accompanying editorial. She did not participate in the study.
A small number of people in all three dosage groups experienced suicidal thoughts or injured themselves over the 12-week follow-up period, the study found. Within the first three weeks alone, two people in the 25-milligram group thought about suicide and two intentionally injured themselves. Two people in the 10-milligram group were suicidal, one self-injured and one was hospitalized for severe depression, the study reported.
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