Treatment with setmelanotide, a melanocortin-4 receptor agonist, led to a significant reduction in BMI in a difficult-to-treat population of patients with hypothalamic obesity.
No approved treatments currently exist for hypothalamic obesity, a condition resulting from hypothalamic damage, characterized by rapid and severe weight gain , and sometimes presenting as insatiable hunger.
Patients were administered age-dependent setmelanotide dose titration for the first 4 weeks, followed by 3.0 mg of subcutaneous setmelanotide daily for 12 weeks, with the total treatment duration being 16 weeks.
Obese Body Mass Index BMI Receptors Chemotherapy Diet Endocrinology Endocrine System Exercise Physical Activity Hypothalmic Injury Nausea Salary Compensation Income Earnings Remuneration Salary Negotiations Surgery Tumor Washington Weight Gain Diarrhea Diarrhoea Practice Management Revenue Weight Management Wound Management Wound Care
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