Self Esteems ecstatic UK tour shows a woman finding her true self
released “I Do This All the Time”, the self-realising, spoken word hit that stopped everyone who heard it in their tracks, there was no sign of what was to come next.Prioritise Pleasure
Approximately 43,000 tickets have been shifted for this sold-out victory lap UK tour, starting in Nottingham. The singer’s days of kicking around in earnest, underachieving indie duo Slow Club must seem like another life., performed in near entirety tonight, Taylor exorcised the ghosts of toxic relationships, thwarted ambitions and social regret via a searingly honest, angry, witty, patriarchy-tackling, thoroughly modern form of maximalist, danceable pop.
Take the opening trio of songs. The ecstatic electronic fuzz of “Prioritise Pleasure” , which sees Taylor punching her chest and tugging at her lilac blue suit, is met with nothing short of hysteria. By the time the soaring hyper-pop-meets-gospel “Fucking Wizardy” is followed by the strutting electro-R’nB of “Moody” the reaction is so wild that Taylor looks genuinely taken aback.
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Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke - BMC MedicineBackground After ischemic stroke (IS), peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-IS and these transcriptional programs reflect changes in immune responses to IS. Dissecting the temporal dynamics of gene expression after IS improves our understanding of immune and clotting responses at the molecular and cellular level that are involved in acute brain injury and may assist with time-targeted, cell-specific therapy. Methods The transcriptomic profiles from peripheral monocytes, neutrophils, and whole blood from 38 ischemic stroke patients and 18 controls were analyzed with RNA-seq as a function of time and etiology after stroke. Differential expression analyses were performed at 0–24 h, 24–48 h, and |48 h following stroke. Results Unique patterns of temporal gene expression and pathways were distinguished for monocytes, neutrophils, and whole blood with enrichment of interleukin signaling pathways for different time points and stroke etiologies. Compared to control subjects, gene expression was generally upregulated in neutrophils and generally downregulated in monocytes over all times for cardioembolic, large vessel, and small vessel strokes. Self-organizing maps identified gene clusters with similar trajectories of gene expression over time for different stroke causes and sample types. Weighted Gene Co-expression Network Analyses identified modules of co-expressed genes that significantly varied with time after stroke and included hub genes of immunoglobulin genes in whole blood. Conclusions Altogether, the identified genes and pathways are critical for understanding how the immune and clotting systems change over time after stroke. This study identifies potential time- and cell-specific biomarkers and treatment targets.
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