Strand Therapeutics has figured out a way to turn the molecule on and off in certain tissues to more precisely treat tumors.
But a major obstacle is how to deliver the molecule to the place in the body that needs to be treated. Fatty bubbles called lipid nanoparticles can carry RNA into cells, and they can ferry it to a wide range of tissues but not to anywhere specific. That’s a problem for cancer, says Jake Becraft, cofounder and CEO of Boston-based Strand Therapeutics, because many cancer treatments “can be incredibly toxic in off-target tissues.” But his company may have found a solution.
To keep IL-12 inside tumors, scientists at Strand designed a set of instructions called a genetic circuit that tells the mRNA to make the inflammatory protein only when it detects the tumor microenvironment. The circuit is designed to sense levels of microRNA—molecules that naturally regulate gene expression and give off different signatures in cancer cells versus healthy ones. The genetic circuit instructs the mRNA to self-destruct if it goes anywhere other than its intended target.
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