Researchers find how skeletal muscle adjusts to high-intensity interval training, including alterations to mechanisms crucial for controlling metabolism and muscular contraction. Research recently published in eLife has provided fresh insight into the effects of high-intensity interval training (
In order to better understand how exercise affects the protein content of the muscles, Hostrup et al. chose eight healthy, untrained male participants for their research. They underwent five weeks of high-intensity cycling training.
According to the study, HIIT increases the number of skeletal muscle proteins crucial for energy metabolism and muscular contraction and chemically alters important metabolic proteins. These findings may help to explain how HIIT boosts metabolism and open the door to further research on the influence of exercise on these processes.
The scientists enlisted eight healthy, untrained male volunteers for their study, who underwent five weeks of intense cycling training. The guys exercised three times each week, cycling for four minutes at a target heart rate of more than 90% of their maximum, followed by a two-minute break. Each session, they went through this process four to five times.
Their analyses showed an increase in the production of proteins used to build mitochondria, which produce energy in cells, and in proteins related to muscle contractions. The team also identified increased acetylation of mitochondrial proteins and enzymes that are involved in the production of cellular energy. Additionally, they observed changes in the number of proteins that reduce the skeletal muscle’s calcium sensitivity, which is essential for muscle contractions.
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