Pyroptotic cells that have been commanded to die have inbuilt mechanisms to reverse the decision.
, but one fate is particularly grisly. Pyroptosis occurs when a cell dies by detonating, typically in response to an infection. In a fiery swan song, a pyroptotic cell sacrifices itself to flood surviving compatriots with its last supply of danger-signaling chemicals called cytokines. The cell’s death is quick and messy, but it’s for the greater good.
Scientists had previously thought that pyroptosis is a one-way street—once set in motion, the decision can’t be reversed. In a recent study published in the journal, Mo and his team found that a cell has an inbuilt mechanism to revoke pyroptosis, allowing it to die another day.
“You can imagine that this is a dangerous process,” says Mo. So, cells have evolved a way to tamper with their ill fate as a way to regulate the consequences. “It’s probably a good idea to have a pause button,” Mo says. He explains that it’s as if a cell is giving itself an out and asking, “‘do you really want to do this?'”
Contrary to common knowledge, says Mo, a pore isn’t static. He theorizes that a cell might pick up on the sudden spike in calcium ions as a signal to backpedal on pyroptosis. In response, the cell alters the composition of its leaky walls by changing how its fatty-molecule constituents pack along the membrane, “and all of a sudden, it’s like the hull of your ship becomes stronger,” says Mo. “And [the pore] just shuts itself.
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