A new study explores how new information is across the sleep-wake cycle. Researchers discovered a new daily rhythm in a kind of synapse that dampens brain activity using a mouse model. These neural connections, known as inhibitory synapses, are rebalanced as we sleep to allow us to consolidate new
The research on mice sheds light on how brain activity is fine-tuned.Researchers discovered a new daily rhythm in a kind of synapse that dampens brain activity using a mouse model. These neural connections, known as inhibitory synapses, are rebalanced as we sleep to allow us to consolidate new information into lasting memories. The results, which were published in the journal, may help explain how subtle synaptic changes improve memory in humans.
“When you are learning new information during the day, neurons are bombarded with excitatory signals from the cortex and many other areas of the brain. To transition this information into a memory, you first need to regulate and refine it—that’s where inhibition comes in,” said Dr. Lu. Humans and mice share similar neural circuits underlying memory storage and other essential cognitive processes. This mechanism may be a way for inhibitory inputs to precisely control the ebb and flow of information between neurons and throughout entire brain networks.
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