Scientists determine structure of a DNAdamage 'first responder' sloan_kettering NatureSMB NatureSMB
What's not captured by this analogy is the fact that our DNA requires constant upkeep to maintain its integrity. Were it not for dedicated DNA repair machinery that routinely fixes mistakes, the information within DNA would be rapidly degraded.
"We know that this attachment is a pivotal step necessary for initiating an effective repair program," says Dirk Remus, aat the Sloan Kettering Institute who studies the fundamentals of DNA replication and repair."But the mechanisms involved are completely obscure." Dr. Remus realized that if these complexes could be viewed at atomic resolution, they would provide a set of freeze-frame images of the individual steps in the repair process. That's when he turned to Dr. Hite's lab for help.to figure out how it works?' And that's what he did."electron microscopy
"When Rich first produced the structure, I thought he got it wrong because it was against all the expectations," Dr. Remus adds."Now, in hindsight, it all makes perfect sense."The 9-1-1 clamp is shaped like a ring. To carry out its function, it needs to surround the broken DNA at the junction between an exposed end of one strand of a double-stranded piece of DNA abutting a single-stranded one.
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