Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222 medrxivpreprint BrighamWomens MeridianClinRes immunogenicity Omicron mRNA COVID19 coronavirus covid SARSCoV2
By Dr. Chinta SidharthanDec 19 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, a team of researchers evaluated the immunogenicity and safety of the coronavirus disease 2019 bivalent messenger ribonucleic acid vaccine mRNA-1273.222 and tested the neutralizing ability of the two bivalent vaccines — mRNA-1273.222 and mRNA-1273.214 — against the newly emergent Omicron subvariants.
Clinical trials have shown that the mRNA-1273.214 bivalent vaccine containing Omicron BA.1 does not cause adverse reactions and elicits a stronger neutralizing antibody response against Omicron BA.1. The vaccine was also seen to be cross-reactive against Omicron subvariants BA.2.75 and BA.4/BA.5. The mRNA-1273 vaccine comprises a single mRNA that codes for the spike glycoprotein of the SARS-CoV-2 Wuhan-Hu-1 strain, while the bivalent vaccine contains an additional mRNA encoding the Omicron BA.4/BA.5 spike glycoprotein.
The immunogenicity assessment objectives included calculating the seroresponse rate difference and geometric mean titer ratio to determine non-inferior neutralizing antibody responses against the D614G mutation carrying ancestral SARS-CoV-2 strain and the Omicron BA.4/BA.5 subvariant, and the superior neutralizing antibody responses against Omicron BA.4/BA.5 based on GMR values four weeks after the administration of the monovalent or bivalent booster vaccine.
The GMT values for neutralizing antibody responses against Omicron BA.4/BA.5 after the administration of the mRNA-1273.222 and mRNA-1273 booster dose were 2324.6 and 488.5, respectively, while those against the ancestral D614G strain were 7322.6 and 5651.4, respectively.
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